Electrochemical behavior of lansoprazole at a multiwalled carbon nanotubes–ionic liquid modified glassy carbon electrode and its electrochemical determination

The electrochemical behavior of lansoprazole (LNS) was investigated at a glassy carbon electrode (GCE) and the GCE modified by a gel containing multiwalled carbon nanotubes (MWCNTs) and a room-temperature ionic liquid (RTIL) of 1-butyl-3-methylimidazolium hexafluorophosphate (BMIMPF6) in 0.10 M phosphate buffer solution of pH 6.8. It was found that an irreversible anodic oxidation peak with an Epa of 1.060 VSCE appeared at the MWCNTs– –RTIL/GCE. Under the optimized experimental conditions a linear calibration curve was obtained over the concentration range from 5.0 μM to 0.20 mM by differential pulse voltammetry with a limit of detection (LOD, S/N = 3) of 0.28 μM. In addition, the novel MWCNTs–RTIL/GCE was also characterized by electrochemical impedance spectroscopy and the proposed method was successfully applied in the quantitative electrochemical determination of LNS content in commercial tablet samples. The determination results met the determination requirements.